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KMID : 1161420130160060544
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Journal of Medicinal Food
2013 Volume.16 No. 6 p.544 ~ p.550
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Chemical Composition and Antioxidant, Anti-Inflammatory, and Antiproliferation Activities of Pomegranate (Punica granatum) Flowers
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Bekir Jalila
Mars Mohamed
Vicendo Patricia
Fterrich Amira
Bouajila Jalloul
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Abstract
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The chemical composition, antioxidant (DPPH and ABTS assays), anti-inflammatory (5-LOX), and cytotoxic (MCF-7) activities from flowers of seven pomegranate varieties (Punica granatum) were investigated. The highest phenolics (330.9±11.3?mg gallic acid equivalent/g dry weight (dw)), flavonoids (29.5±0.8?mg quercetin equivalent/g dw), tannins (30.6±0.6?mg catechin equivalent/g dw), and anthocyanins (0.70±0.03?mg cyanidin-3-glucoside equivalent/g dw) content were determined in the Chetoui (CH) variety. It was found that Garsi (GR) (IC50=4.9±0.2?mg/L by ABTS assay) and Zaghwani (ZG) (IC50=3.9±0.2?mg/L by ABTS assay) varieties exhibited the highest antioxidant activity. For the anti-inflammatory activity, all varieties were active; the ZH variety was the strongest (2.5±0.1?mg/L). The CH, ES, and RA pomegranate varieties were not active against human breast cancer cells MCF-7, whereas inhibition was more evident with extracts from ZH and GR varieties (IC50=33.00±2.64 and 35.00±4.58?mg/L, respectively). Statistical analysis showed that the variety factor influenced significantly (P<.01) the chemical composition and biological activities of pomegranate flowers.
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KEYWORD
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anti-inflammatory, antioxidant, cytotoxic, flowers, phenolics, Punica granatum, variety
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